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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#_3 http://www.w3.org/ns/prov#value Few studies have addressed the consequences of physical interactions between NK and T cells, as well as physical interactions among NK cells themselves. We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on NK cells and CD48 on T cells. Furthermore, 2B4/CD48 interactions between NK cells also enhanced proliferation of NK cells in response to IL-2. Overall, these results suggest that NK cells augment the proliferation of neighboring T and NK cells through direct cell-cell contact. These results provide new insights into NK cell-mediated control of innate and adaptive immunity and demonstrate that receptor/ligand-specific cross talk between lymphocytes may occur in settings other than T-B cell or T-T cell interactions. http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15210772 http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15210772 http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#_3 http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w#pubinfo http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w http://purl.org/dc/terms/created 2014-07-03T14:30:25.123+02:00 http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RARm4Eg3xrZMmJ1XMA3ZJlTQQPtYaMXUGMHitvKABBL2w http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234