. . . . . . . . . . . . . . . . "cat(p(HGNC:VHL)) -| p(HGNC:HIF1A)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "VHL loss of function results in a marked increase in HIF-1 activity in non- hypoxic conditions because of impaired VHL-dependent ubiquitylation and proteasomal degradation of HIF-1a and HIF-2a. Although the O2-dependent regulation of transactivation function is still intact, FIH-1 might become limiting under conditions of HIF-1a and HIF-2a overexpression, leading to increased transcriptionally active HIF-1 under nonhypoxic conditions in VHL-null cells." . . "Selventa" . . . . "2014-07-03T14:30:16.656+02:00"^^ . . .