sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_8 ; pav:version "1.4" . sub:_7prov:value "CBP was initially characterized as a coactivator required for efficient transactivation of cAMP-response elementbinding protein, and p300 was first identified as a coactivator of the adenovirus E1A oncoprotein. CBP and p300 share many functional properties: both of them function as coactivators for multiple nuclear receptors as well as p53 and nuclear factor-eB [9], both possess intrinsic histone acetyltransferase activity, and both can recruit histone acetyltransferase and CBP/p300-associated factor [26]. Besides, CBP/p300 interacts with members of the SRC family and synergizes with SRC-1 in the transactivation of the ER and the PR" ; prov:wasQuotedFrompubmed:12223121 . sub:_8rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:12223121 ; prov:wasDerivedFrombeldoc: , sub:_7 . }