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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAS5MR9Tri5YEXSNJx4agxurWFK_St8HbIb5hTLM4bVyg#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAS5MR9Tri5YEXSNJx4agxurWFK_St8HbIb5hTLM4bVyg#_7 http://www.w3.org/ns/prov#value CBP was initially characterized as a coactivator required for efficient transactivation of cAMP-response elementbinding protein, and p300 was first identified as a coactivator of the adenovirus E1A oncoprotein. CBP and p300 share many functional properties: both of them function as coactivators for multiple nuclear receptors as well as p53 and nuclear factor-eB [9], both possess intrinsic histone acetyltransferase activity, and both can recruit histone acetyltransferase and CBP/p300-associated factor [26]. 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