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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#_2 http://www.w3.org/ns/prov#value In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes. These monocytes enter the vessel wall, differentiate into macrophages, and subject the modified lipoproteins to endocytosis through scavenger receptor pathways. This unrestricted uptake, which is not limited by intracellular cholesterol levels, eventually leads to the formation of lipid-filled foam cells, the initial step in atherosclerosis http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10669623 http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10669623 http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#_2 http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24#pubinfo http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24 http://purl.org/dc/terms/created 2014-07-03T14:29:49.945+02:00 http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASD8S6ZeGbdCy6Sj7AAT2OUOo_9gzEDP1mh53jChxO24 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234