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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#_3 http://www.w3.org/ns/prov#value CORTICOTROPIN regulates the steroidogenic capacity, size, and structural integrity of the adrenal cortex through a series of actions involving changes in gene expression; however, only a limited number of CORTICOTROPIN-regulated genes have been identified, and these only partly account for the global effects of CORTICOTROPIN on the adrenal cortex. In this study, a National Institute on Aging 15K mouse cDNA microarray was used to identify genome-wide changes in gene expression after treatment of Y1 mouse adrenocortical cells with CORTICOTROPIN. CORTICOTROPIN affected the levels of 1275 annotated transcripts, of which 46% were up-regulated. The up-regulated transcripts were enriched for functions associated with steroid biosynthesis and metabolism; the down- regulated transcripts were enriched for functions associated with cell proliferation, nuclear transport and RNA processing, including alternative splicing. A total of 133 different transcripts, i.e. only 10% of the CORTICOTROPIN-affected transcripts, were represented in the categories above; most of these had not been described as CORTICOTROPIN-regulated previously. The contributions of protein kinase A and protein kinase C to these genome-wide effects of CORTICOTROPIN were evaluated in microarray experiments after treatment of Y1 cells and derivative protein kinase A-defective mutants with pharmacological probes of each pathway. Protein kinase A-dependent signaling accounted for 56% of the CORTICOTROPIN effect; protein kinase C-dependent signaling accounted for an additional 6%. These results indicate that CORTICOTROPIN affects the expression profile of Y1 adrenal cells principally through cAMP- and protein kinase A- dependent signaling. The large number of transcripts affected by CORTICOTROPIN anticipates a broader range of actions than previously appreciated. http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16484322 http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16484322 http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#_3 http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg#pubinfo http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg http://purl.org/dc/terms/created 2014-07-03T14:30:41.612+02:00 http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASFNsnf0DYs4EhOtijfs2XwVBjj9y1u3O1RH4waa0Vzg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234