http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#Head http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#assertion http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#provenance http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#pubinfo http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#assertion http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_2 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6735 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_3 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=16500 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.lgcstandards-atcc.org/Products/All/CRL-1573.aspx http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_3 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_1 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:LYN)) => p(HGNC:DAPP1,pmod(P,Y,139)) http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_5 http://www.w3.org/ns/prov#value Src, Lyn and Lck tyrosine kinases phosphorylate DAPP1 at Tyr(139) in vitro at similar rates in the presence or absence of PtdIns(3,4,5)P(3), and overexpression of these kinases in HEK-293 cells induces the phosphorylation of Tyr(139). co-expression of DAPP1 with Src, Lyn or Lck induced a very high level of phosphorylation of DAPP1 at Tyr139, even in unstimulated cells, which was not increased further by agonist stimulation of cells. As Src-family kinases activate the PI 3-kinase pathway in many cells [1], it is possible that the overexpression of Src, Lyn or Lck in HEK-293 cells induces the activation of PI 3-kinase, thereby promoting DAPP1 phosphorylation in unstimulated cells. As Src-family tyrosine kinases are located at the plasma membrane by virtue of myristoylation and palmitoylation of their N-termini [26], it is likely that the role of PtdIns(3,4,5)P3 is to recruit DAPP1 to the cell membrane, where it can be phosphorylated with Src-family tyrosine kinases. http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10880360 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10880360 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#_5 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM#pubinfo http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://purl.org/dc/terms/created 2014-07-03T14:29:51.492+02:00 http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASLWc0_U4pa7IEMV4_FTDLyetkLEL2y4BWQsG60sohkM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234