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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#_5 http://www.w3.org/ns/prov#value We report here that mice with renal-specific inactivation of HNF1beta develop polycystic kidney disease. We show that renal cyst formation is accompanied by a drastic defect in the transcriptional activation of Umod, Pkhd1 and Pkd2 genes In vivo chromatin immunoprecipitation experiments demonstrated that HNF1beta binds to several DNA elements in murine Umod, Pkhd1, Pkd2 and Tg737/Polaris genomic sequences http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15029248 http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15029248 http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#_5 http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk#pubinfo http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk http://purl.org/dc/terms/created 2014-07-03T14:30:21.679+02:00 http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASMCRRBqdFppFBN4qhVUTanRRdb06fPCTilgLkYUX5rk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234