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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#_4 http://www.w3.org/ns/prov#value Nuclear factor kappaB (NF-kappaB) plays an important role in the transcriptional regulation of genes involved in inflammation and cell survival. In this study, we demonstrated that NF-kappaB-dependent gene expression was inhibited by E1A in poly(ADP)-ribose polymerase-1 knock out (PARP-1 (-/-)) cells complemented with wild type PARP-1 after tumor necrosis factor alpha (TNFalpha) or lipopolysaccharide (LPS) treatment. PARP-1 and p300 synergistically coactivated NF-kappaB-dependent gene expression in response to TNFalpha and LPS. Furthermore, PARP-1 interacted directly with p300 and enhanced the interaction of NF-kappaB1/p50 to p300. The C terminus, harboring the catalytic domain of PARP-1 but not its enzymatic activity, was required for complete transcriptional coactivation of NF-kappaB by p300 in response to TNFalpha and LPS. Together, these results indicate that PARP-1 acts synergistically with p300 and plays an essential regulatory role in NF-kappaB-dependent gene expression. http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12960163 http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12960163 http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#_4 http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU#pubinfo http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU http://purl.org/dc/terms/created 2014-07-03T14:30:16.334+02:00 http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASO1y_CLXgubOz6FKqKe3E9E_bafqSAeFWQrgG0ZAkCU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234