http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#Head http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#assertion http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#provenance http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#pubinfo http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#assertion http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0007049 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0009314 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"response to radiation") -> bp(GO:"cell cycle") http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_2 http://www.w3.org/ns/prov#value Activation of the tumor suppressor p53 by DNA damage induces either cell cycle arrest or apoptosis, but what determines the choice between cytostasis and death is not clear. In this report, we show that the E1A-binding p300 nucleoprotein is a key determinant of p53-dependent cell fate in colorectal cancer cells: absence of p300 increases apoptosis in response to DNA damage. In addition, p300-deficient (p300(-)) cells fail to undergo G(1)/S arrest after UV irradiation. These abnormalities are associated with prolongation of p53 stability, reduced p53-acetylation, blunting of MDM2 activation, failure to transactivate p21, and a disproportionate increase in PUMA levels. When xenografted, p300(-) cells are more sensitive to chemotherapy with doxorubicin. These results show that p300 is a key regulator of the p53 response and suggest that p300 inhibition could be used to modulate chemotherapy. http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15123817 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15123817 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#_2 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM#pubinfo http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://purl.org/dc/terms/created 2014-07-03T14:30:23.175+02:00 http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASjoioybDgykCoAotp_kGwg7tsnvJvvDY3c1Vk6JvnkM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234