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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#_3 http://www.w3.org/ns/prov#value The cellular response to osmotic stress ensures that the concentration of water inside the cell is maintained within a range that is compatible with biologic function. Single cell organisms are particularly dependent on mechanisms that permit adaptation to osmotic stress because each individual cell is directly exposed to the external environment. Mammals, however, limit osmotic stress by establishing an internal aqueous environment in which intravascular water and electrolytes are subject to sensitive and dynamic, organism-based homeostatic regulation. Recent studies of NFAT5/TonEBP, an essential mammalian osmoregulatory transcription factor, demonstrate the unexpected yet critical significance of cell-based osmotic regulation in vivo. These results highlight the fundamental importance of maintaining intracellular water homeostasis in the face of varying cellular metabolic activity and distinct tissue microenvironments. http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15965902 http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15965902 http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#_3 http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU#pubinfo http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU http://purl.org/dc/terms/created 2014-07-03T14:30:36.081+02:00 http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASsJ4WnG1CVdaFQUNZoxJTcJ7SDDOshEQr1Cq8oLCGzU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234