. . . . . . . . . . . . . . . . . . . . "kin(p(PFH:\"AKT Family\")) -> complex(p(HGNC:TOPBP1),p(HGNC:E2F1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "We now show that the regulation of E2F1 by TopBP1 involves the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway, and is independent of pocket proteins. Akt phosphorylates TopBP1 in vitro and in vivo.... The Akt-dependent oligomerization is crucial for TopBP1 to interact with and repress E2F1." . . "Selventa" . . . . "2014-07-03T14:30:46.240+02:00"^^ . . .