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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#_3 http://www.w3.org/ns/prov#value We tested the hypothesis that up-regulation of DNA methyltransferase 1 (DNMT1) will lead to methylation and silencing of uPA and inhibition of the invasiveness of metastatic breast cancer cells. Since RAS was previously shown to up-regulate DNA methylation, we examined the effects of ectopic expression of constitutively active RAS on methylation and expression of uPA. http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15618232 http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15618232 http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#_3 http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls#pubinfo http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls http://purl.org/dc/terms/created 2014-07-03T14:30:30.561+02:00 http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASwEZFafwPdGGbxqzYyylQ64S7k9qzrTgXEQRDhIm4Ls http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234