http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#Head http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#assertion http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#provenance http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#assertion http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5013 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_1 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/Tetradecanoylphorbol%20acetate http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:HMOX1) http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_3 http://www.w3.org/ns/prov#value View this table: [in this window] [in a new window] TABLE 1 Summary of the various functions of HO isoforms, their tissue distribution, and gene regulation Maines et al. (1986) were the first to report the identification of a second form of HO from rat liver microsomes, designated HO-2. Only recently, a third isoform, HO-3, was discovered (McCoubrey et al., 1997). HO-1 and HO-2 share little similarity in amino acid sequence (40%), whereas the HO-2 and HO-3 isoform are far more homologous (90%). All HO isoforms are highly conserved among species in evolution. HO is expressed in virtually all life forms; in prokaryotic bacteria as well as in fungi, plants, and humans, regulating a wide spectrum of cellular processes (Terry et al., 2002). The homology between rat, mouse, and human is for HO-1 and HO-2 proteins higher than 80% and 90%, respectively. Under normal physiological conditions, most cells express low or undetectable levels of HO-1 protein, whereas HO-2 proteins are constitutively expressed. HO-3 protein expression awaits further characterization. HO-2 transcription is only up-regulated by few agents, such as opiates and adrenal glucocorticoids (Li and David Clark, 2000; Liu et al., 2000). HO-1 gene expression is highly inducible by more diverse stimuli than any other enzyme described to date (Maines, 1997) and involves a multitude of signaling pathways (Table 2) (Immenschuh and Ramadori, 2000). HO-1 expression is mainly regulated at the transcriptional level. View this table: [in this window] [in a new window] TABLE 2 Selection of different inducers of HO-1 gene expression http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12869663 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12869663 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#_3 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://purl.org/dc/terms/created 2014-07-03T14:30:14.795+02:00 http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAT1PH74aY54E059NkAwcoA3D0nmNVu725Hk7CaM4eeTU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234