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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#_3 http://www.w3.org/ns/prov#value Gene expression was measured during t10c12-CLA-induced body fat reduction in a polygenic obese line of mice. Adult mice (n = 185) were allotted to a 2 x 2 factorial experiment consisting of either nonobese (ICR-control) or obese (M16-selected) mice fed a 7% fat, purified diet containing either 1% linoleic acid (LA) or 1% t10c12-CLA. Body weight (BW) by day 14 was 12% lower in CLA- compared with LA-fed mice (P of epididymal, mesenteric, and brown adipose tissues, as a percentage of BW, in both lines by 30, 27, and 58%, respectively, and increased liver weight/BW by 34% (P per day) from epididymal adipose (days 5 and 14) of the obese mice to analyze gene expression profiles using Agilent mouse oligo microarray slides representing 20,000 genes. Numbers of genes differentially expressed by greater than or equal to twofold in epididymal adipose (days 5 and 14) were 29 and 125, respectively. It was concluded that, in adipose tissue, CLA increased expression of uncoupling proteins (1 and 2), carnitine palmitoyltransferase system, tumor necrosis factor-alpha (P caspase-3 but decreased expression of peroxisome proliferator-activated receptor-gamma, glucose transporter-4, perilipin, caveolin-1, adiponectin, resistin, and Bcl-2 (P candidate genes that will be useful in elucidating mechanisms of adipose delipidation. http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15888570 http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15888570 http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#_3 http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to#pubinfo http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to http://purl.org/dc/terms/created 2014-07-03T14:30:35.291+02:00 http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAT5JDskdURGjh-Gc8n6FrlRsrRstdg17et_tCp7Xj9to http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234