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http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATDoMZ1nbmJQzsWogJAjcXXw0sn72h6_AmibWpxgDuFo#_9 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RATDoMZ1nbmJQzsWogJAjcXXw0sn72h6_AmibWpxgDuFo#_8 http://www.w3.org/ns/prov#value The expression and action of integrins are predominantly localized to the focal adhesion complex as originally demonstrated in fibroblasts. Focal adhesion complexes are the structural connection between the ECM and the cytoskeleton. Here, transmembrane signaling is mediated by integrins that cluster with dozens of cytoskeletal proteins and signaling molecules. Interestingly, integrins not only convey signals from the ECM into the cell (outside-in), but also react to cytoplasmic alterations by altering their capability to adhere to the ECM (inside-out). After collagen-activation of integrins, the incoming signal is translated into increased tyrosine phosphorylation. Unlike the DDR, which have an intrinsic catalytic activity, integrins recruit cytoplasmic tyrosine kinases, in particular focal adhesion kinase (FAK), a 125 kDa multi-domain protein. The beta1 integrin cytoplasmic tail interacts with paxillin and talin, which both complex FAK [75]. The detailed mechanism, how FAK interacts with these proteins and becomes activated in response to integrin ligation, is not fully understood. 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