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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#_3 http://www.w3.org/ns/prov#value Here, we investigated the role of ROS in the regulation of PHAS-I phosphorylation on Thr-70 and Ser-65, an event required for the release of eIF4E from PHAS-I. Ang II-induced Ser-65 phosphorylation was ROS-dependent as assessed by pretreatment with ebselen (3.6 +/- 0.2 versus 1.1 +/- 0.2), diphenylene iodonium (3.6 +/- 0.2 versus 1.0 +/- 0.1), and N-acetyl cysteine (3.6 +/- 0.2 versus 1.2 +/- 0.1), but Ang II-stimulated phosphorylation of Thr-70 was ROS-insensitive. http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12860993 http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12860993 http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#_3 http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg#pubinfo http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg http://purl.org/dc/terms/created 2014-07-03T14:30:14.736+02:00 http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RATKdiphCIxd3Dj5c98PFp1fgfSZ5FBYGq4xmja6D2nxg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234