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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#_3 http://www.w3.org/ns/prov#value We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups of 10- to 11-month-old male C57Bl6 mice that were either fasted for 18 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 months and compared with nonfasted control (CO) mice. Only a few transcripts of F and SCR were differentially expressed compared with CO mice. In contrast, 345 transcripts of 6,266 genes found to be expressed in WAT were altered significantly by LCR. The expression of several genes encoding proteins involved in energy metabolism was increased by LCR. Further, many of the shifts in gene expression after LCR are known to occur during adipocyte differentiation. Selected LCR-associated alterations of gene expression were supported by quantitative reverse transcriptase-polymerase chain reaction, histology, and histochemical examinations. Our data provide new insights on the metabolic state associated with aging retardation by LCR. http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14688200 http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14688200 http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#_3 http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4#pubinfo http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4 http://purl.org/dc/terms/created 2014-07-03T14:30:19.274+02:00 http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RATUz2qqpndl6c4db1ReB2ADp0n6kNvQBl4l4_BbQVjh4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234