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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#_4 http://www.w3.org/ns/prov#value Using a stable SUZ12 knockdown cell line, we show SUZ12 knockdown results in cell growth defects, which correlate with genome-wide alteration on H3-K27 methylation as well as upregulation of a number of Hox genes. Chromatin immunoprecipitation (ChIP) assay identified a 500 bp region located 4 kb upstream of the HoxA9 transcription initiation site as a SUZ12 binding site, which responds to SUZ12 knockdown and might play an important role in regulating HoxA9 expression. http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15225548 http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15225548 http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#_4 http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ http://purl.org/dc/terms/created 2014-07-03T14:30:25.299+02:00 http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RATZCIIAbJw9_ru-7oGRdNFDtLrzgsP390nVYF4uqbGEQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234