@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RAU-jWAqmoSJBdswIneCuFj-IOCvLnvmZJyK-_H3WgY9Y> .
@prefix sub: <http://purl.org/np/RAU-jWAqmoSJBdswIneCuFj-IOCvLnvmZJyK-_H3WgY9Y#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0001156> biolink:category biolink:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0001156>;
    rdf:predicate biolink:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB01224>;
    a rdf:Statement;
    rdfs:label "Antipsychotics have been found to reduce BPD symptoms including aripiprazole (mean daily dose: 15 mg); ziprasidone (mean daily dose: 20 to 80 mg), olanzapine (mean daily dose: 5 to 9 mg, daily dose range 5 to 20 mg), haloperidol (mean daily dose 5 mg, daily dose range 4 to 16 mg), Quetiapine XL (at a daily dose of 150 mg). The empirically use of antipsychotics in patients with BPD are considered as off-label use.";
    biolink:association_type biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:cohort;
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/28825781/>;
    biolink:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "Adults";
    biolink:category biolink:Cohort .
  
  <https://go.drugbank.com/drugs/DB01224> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "Bj6mmhqAZhZ5VWszscaNOprKe/ybwQAiXnRntRSaFa4Olj+ifNWfgKL6avCyUEBqYMK2VqUzQyUFOitr5SaffLJbFq5mqibLsUKp/9Rd6IUxWihmEUowrGcgwDIeuvbvTSQdD1wi5l3U4lcyPVqlLgfUbbIm7oxSSnyYpetLzVE=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2021-05-28T22:38:56.660+02:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0002-7641-6446;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}