http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#Head http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#assertion http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#provenance http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#assertion http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5392 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_1 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0030593 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"neutrophil chemotaxis") -> r(HGNC:IER3) http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_3 http://www.w3.org/ns/prov#value To investigate the cellular fate and function of polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds, we used a human skin-wounding model and microarray technology to define differentially expressed genes in PMNs from peripheral blood, and PMNs that had transmigrated to skin lesions. After migration to skin lesions, PMNs demonstrated a significant transcriptional response including genes from several different functional categories. The up-regulation of anti-apoptotic genes concomitant with the down-regulation of proapoptotic genes suggested a transient anti-apoptotic priming of PMNs. Among the up-regulated genes were cytokines and chemokines critical for chemotaxis of macrophages, T cells, and PMNs, and for the modulation of their inflammatory responses. PMNs in skin lesions down-regulated receptors mediating chemotaxis and anti-microbial activity, but up-regulated other receptors involved in inflammatory responses. These findings indicate a change of responsiveness to chemotactic and immunoregulatory mediators once PMNs have migrated to skin lesions and have been activated. Other effects of the up-regulated cytokines/chemokines/enzymes were critical for wound healing. These included the breakdown of fibrin clots and degradation of extracellular matrix, the promotion of angiogenesis, the migration and proliferation of keratinocytes and fibroblasts, the adhesion of keratinocytes to the dermal layer, and finally, the induction of anti-microbial gene expression in keratinocytes. Notably, the up-regulation of genes, which activate lysosomal proteases, indicate a priming of skin lesion-PMNs for degradation of phagocytosed material. These findings demonstrate that migration of PMNs to skin lesions induces a transcriptional activation program, which regulates cellular fate and function, and promotes wound healing. http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15187151 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15187151 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#_3 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://purl.org/dc/terms/created 2014-07-03T14:30:24.181+02:00 http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUDCT18eWJcZY_ZCO4q7Xmbed9V4OgMsGDsQN7vixY0k http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234