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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUEnr2wzZkS_miZOm1XdPqJHp4pgfu_jPtOTR3YQNJ2s#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAUEnr2wzZkS_miZOm1XdPqJHp4pgfu_jPtOTR3YQNJ2s#_5 http://www.w3.org/ns/prov#value The mechanism of adiponectin action in endothelial cells has been further investigated. TNF-A activates nuclear transcription factor NF-KB in these cells by stimulating protein kinase NIK (NF-kB inducing kinase), which phosphorylates the NF-kB inhibitor, IkB, initiating its degradation and thus leading to NF-KB activation. 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