@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAUIXYzHkz5GSjrPq1jKMim1IHfjcD8Pu_SnyPfb_SZvA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAUIXYzHkz5GSjrPq1jKMim1IHfjcD8Pu_SnyPfb_SZvA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix pfh: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 belv:variantOf pfh:AKT%20Family;
    a proteinModification:, psimod:00696 .
  
  sub:_2 occursIn: mesh:D002289, mesh:D008168, atcc:CRL-5889.aspx, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:18723;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:nicotine) -> p(PFH:\"AKT Family\",pmod(P,S,473))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "1.4" .
  
  sub:_3 prov:value "To investigate whether nicotine or NNK could stimulate the Akt pathway in fully transformed lung cancer cells, we used two NSCLC cell lines (H157 and H1703) and one small cell lung cancer (SCLC) cell line (H69) to assess phosphorylation of Akt at S473, which is indicative of Akt activation. Nicotine or NNK rapidly increased Akt activation in all three cell lines. Note: Nicotine:  2- to 3-fold within 15--30 min (Figure 1A). NNK: 2- to 3-fold induction observed by 30 min (Figure 1B). ";
    prov:wasQuotedFrom pubmed:15790591 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15790591;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:33.605+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}