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[To clarify the role of cytoplasmic accumulation of ?-catenin in oral squamous cell carcinoma (SCC), the cDNA of a mutant form of ?-catenin that lacks the entire region with the glycogen synthase kinase-3 ? (GSK-3?)-specific phosphorylation site was transfected into Ca9-22 cells whose ?-catenin had been expressed predominantly at the membrane, and permanent cell lines expressing aberrant ?-catenin in the cytoplasm and nucleus were produced.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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