[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0005525" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_2" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5173" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_3", "@type" : [ "http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000", "http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696" ], "http://www.selventa.com/vocabulary/variantOf" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1097" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_4", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_3" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "gtp(p(HGNC:HRAS)) -> p(HGNC:BRAF,pmod(P,S,445))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_6" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_5", "http://www.w3.org/ns/prov#value" : [ { "@value" : "However, unlike Raf-1, the phosphorylation of B-Raf at Ser(445) was constitutive and was only moderately increased by expression of constitutively active H-Ras or constitutively active PAK1. These data demonstrate that B-Raf activity is autoregulated, that constitutive phosphorylation of Ser(445) primes B-Raf for activation, and that a key feature of phosphorylation within the activation loop or of oncogenic mutations within this region is to block autoinhibition." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15710605" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_6", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15710605" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#_5" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:32.502+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAUY_43aK5nyeQwRIP98p38QNopwsw4OUeJuxOLm_91fU#pubinfo" } ]