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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#_4 http://www.w3.org/ns/prov#value We reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor family, plays a key role in nitric oxide (NO)-mediated apoptosis of macrophages and pancreatic beta cells. We also showed that the cytosolic chaperone pair of hsp70 and dj1 (hsp40/hdj-1) or dj2 (HSDJ/hdj-2) prevents NO-mediated apoptosis upstream of cytochrome c release from mitochondria. To analyze roles of the chaperone pair in preventing apoptosis, RAW 264.7 macrophages stably expressing hsp70 and dj1 or dj2 were established. The chaperone pair prevented LPS/IFN-gamma-induced and NO-mediated apoptosis downstream of CHOP induction. http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14752510 http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14752510 http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#_4 http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI http://purl.org/dc/terms/created 2014-07-03T14:30:20.033+02:00 http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUhAtCDOiUODR6tM8mUWtJNlCJegEWaZjo-DjiStcNbI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234