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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#_5 http://www.w3.org/ns/prov#value Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta with high mortality. Although nonsurgical treatment for AAA is much awaited, few options are available because its molecular pathogenesis remains elusive. Here, we identify JNK as a proximal signaling molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of phosphorylated JNK. We show that JNK programs a gene expression pattern in different cell types that cooperatively enhances the degradation of the extracellular matrix while suppressing biosynthetic enzymes of the extracellular matrix. Selective inhibition of JNK in vivo not only prevented the development of AAA but also caused regression of established AAA in two mouse models. Thus, JNK promotes abnormal extracellular matrix metabolism in the tissue of AAA and may represent a therapeutic target. http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16311603 http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16311603 http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#_5 http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s http://purl.org/dc/terms/created 2014-07-03T14:30:39.794+02:00 http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUjGarOFl0dSiUAYqr_DDKV7aTnj7AGCsmUDIgnccO8s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234