. . . . . . . . . . . . . . . . "p(MGI:Creb1,pmod(P,S,133)) => tscript(p(MGI:Creb1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "The ability of Tpl2 to regulate COX-2 expression depends on ERK signals that activate p90Rsk and Msk1, which in turn phosphorylate CREB, a key regulator of COX-2 transcription. The ERK phosphorylates p90Rsk at serine-364, 381 and threonine-360, which in turn phosphorylates Creb1 at serine-133 in cells treated by the LPS. The ERK mediated phosphorylation of p90Rsk was abrogated in Tpl2-/- cells. {Tpl2 Official Gene Symbol: MAP3K8, p90Rsk Official Gene Symbol: Rps6ka1, Msk1 Official Gene Symbol: Rps6ka5}" . . "Selventa" . . . . "2014-07-03T14:30:05.953+02:00"^^ . . .