. . . . . . . . . . . . . "path(SDIS:\"Type II diabetes\") positiveCorrelation p(HGNC:PTPN1)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Phosphotyrosine phosphatases (PTPases). PTPases are responsible for dephosphorylation of the insulin receptor and its substrates, and hence, turning off the insulin signal. To date, no insulin receptor-specific phosphatase has been identified. Total membrane-bound tyrosine phosphatase activity is increased in skeletal muscle of type 2 diabetic patients (158). Immunodepletion experiments in muscles from these diabetic patients and obese individuals suggest that especially two phosphatases, protein-tyrosine phosphatase 1B (PTP-1B) and leukocyte antigen-related (LAR) phosphatase, are mainly responsible for this increase (159)." . . "Selventa" . . . . "2014-07-03T14:29:46.605+02:00"^^ . . .