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[Biochemically, deposition of the ?-amyloid (A?) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of familial AD (FAD) and cerebral amyloid angiopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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