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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#_6 http://www.w3.org/ns/prov#value Phox2a and Phox2b transactivate the promoter of the gene encoding the noradrenergic biosynthetic enzyme, dopamine beta-hydroxylase (DBH), and dHAND potentiates the activity of Phox2a. In this study, we use chromatin immunoprecipitation assays to identify target genes of the Phox2 proteins and dHAND. All three proteins are bound to the DBH and PHOX2B promoter regions in SH-SY5Y neuroblastoma cells. The interaction between Phox2a and dHAND is analyzed by fluorescent anisotropy, which demonstrates that dHAND causes an eightfold increase in the affinity of Phox2a for its recognition sites on the DBH promoter region. http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16280598 http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16280598 http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#_6 http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4 http://purl.org/dc/terms/created 2014-07-03T14:30:39.412+02:00 http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVC2Gbgq55PRWzZqahnC1nkORmLoxmdKXyHXQXYOXjC4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234