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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#_5 http://www.w3.org/ns/prov#value ere, we show that the Foxn4 winged helix/forkhead transcription factor is expressed in a subset of mitotic progenitors during mouse retinogenesis. Targeted disruption of Foxn4 largely eliminates amacrine neurons and completely abolishes horizontal cells, while overexpression of Foxn4 strongly promotes an amacrine cell fate. These results indicate that Foxn4 is both necessary and sufficient for commitment to the amacrine cell fate and is nonredundantly required for the genesis of horizontal cells. Furthermore, we provide evidence that Foxn4 controls the formation of amacrine and horizontal cells by activating the expression of the retinogenic factors Math3, NeuroD1, and Prox1. http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15363391 http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15363391 http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#_5 http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw http://purl.org/dc/terms/created 2014-07-03T14:30:27.523+02:00 http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVJiIW_hXZFdDhX1dCLXjUcLLCfIhQ7oYFuUK0sWqpWw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234