http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#Head http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#assertion http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#provenance http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/C1q%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.ebi.ac.uk/chebi/searchId.do?chebiId=26523 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/C1q%20Complex http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#assertion http://www.w3.org/2000/01/rdf-schema#label complex(NCH:"C1q Complex") -> a(CHEBI:"reactive oxygen species") http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_2 http://www.w3.org/ns/prov#value Alzheimer's disease (AD) remains one of the most challenging brain disorders facing modern medicine. Neuronal loss underlies the pathogenesis of AD and can occur, in part, by oxidative stress, by beta-amyloid peptide (Abeta), and by excitotoxins. The complement cascade, especially C1q, may affect reactive oxygen species (ROS) and mediate neuronal injury during AD. We demonstrate that incubation of neurons with purified C1q results in increased ROS, which can be partially blocked by low concentrations of Abeta. C1q-binding sites on neurons were demonstrated by 125I-C1q-binding and immunofluorescence tests performed on primary neurons. The blocking of neuronal calreticulin by its antibody abrogated ROS by C1q. We suggest that the C1q may be an important factor contributing to neuronal oxidative stress and neuronal demise during AD. http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12576225 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12576225 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#_2 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://purl.org/dc/terms/created 2014-07-03T14:30:09.938+02:00 http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVKb_sDMYsRu9C9JGqHmEUiYHO41zp2S0KE3a4D0SYos http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234