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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVVOXsEe3n8hJ7Lbn-p5sCoQkXmvktKcWZn1iXj98HgY#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAVVOXsEe3n8hJ7Lbn-p5sCoQkXmvktKcWZn1iXj98HgY#_4 http://www.w3.org/ns/prov#value Intratumoral hypoxia and genetic alterations can lead to HIF-1a overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. 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