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[ATM ('mutated in ataxia-telangiectasia') and p53 are two gene products that are believed to play a major role in maintaining the integrity of the genome such that alterations in these gene products may contribute to increased incidence of genomic changes such as deletions, translocations, and amplifications, which are common during oncogenesis. p53 is a critical participant in a signal transduction pathway that mediates either a G1 arrest or apoptosis in response to DNA damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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