. . . . . . . . . . . . . . . . . . . "bp(GO:\"endothelial cell activation\") -> cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3)))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "In addition, avb3 has been shown to bind MMP-2, in an RGD-independent way, thereby localizing MMP-2-mediated matrix degradation to the endothelial cell surface (28, 58). avb3 is nearly undetectable on quiescent endothelium, but is highly upregulated during cytokine or tumor-induced angiogenesis. In activated endothelium avb3 suppresses the activity of both p53 and the p53-inducible cell-cycle inhibitor p21WAF1/CIP1, while increasing the Bcl2:Bax ratio, resulting in an anti-apoptotic effect (226)." . . "Selventa" . . . . "2014-07-03T14:29:54.195+02:00"^^ . . .