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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVuKc8x2mU6FMjORecjvirRV-wy6vesZaK9ECUWFoVlI#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAVuKc8x2mU6FMjORecjvirRV-wy6vesZaK9ECUWFoVlI#_3 http://www.w3.org/ns/prov#value As will be discussed below, reduction of biliverdin, a kinase inhibitor, is an important aspect of regulatory activity of BVR. BVR is the product of a single-copy gene that, in the rat, is 17,025 bp in length and consists of seven exons and six introns (38) (GenBank). The human BVR gene has eight exons, with the initiation codon in exon 2. Exon 5 includes the most strongly conserved motif, which is found in every oxidoreductase (30). In the rat, the ~1.6-kb transcript is expressed sparingly in organs such as the testis and the thymus but abundantly in others such as the kidney, spleen, liver, and brain. The promoter region of the human and rat genes contain consensus sequence elements (38) associated with regulation of transcriptional activity, embryonic gene expression, and response to hyperthermia (12, 39). 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