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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#_4 http://www.w3.org/ns/prov#value In fibroblasts, Shp2 undergoes phosphorylation at two C-terminal tyrosyl residues in response to some (fibroblast growth factor and platelet-derived growth factor (PDGF)) but not all (epidermal growth factor and insulin-like growth factor) growth factors. To clarify the role of Shp2 tyrosyl phosphorylation, we infected Shp2-mutant fibroblasts with retroviruses expressing wild type Shp2 or mutants of either (Y542F or Y580F) or both (Y542F,Y580F) C-terminal tyrosines. Compared with wild type cells, ERK activation was decreased in Y542F- or Y580F-infected cells in response to fibroblast growth factor and PDGF but not the epidermal growth factor. http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12923167 http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12923167 http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#_4 http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4 http://purl.org/dc/terms/created 2014-07-03T14:30:15.773+02:00 http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWA12rjmZ8WQt_pWZOfXQjHlOXZ1E19zheOPmmYoQCS4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234