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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#_4 http://www.w3.org/ns/prov#value Here we show that CRIM1 can interact with both BMP4 and BMP7 via the CRR-containing portion of the protein and in so doing acts as an antagonist in three ways. CRIM1 binding of BMP4 and -7 occurs when these proteins are co-expressed within the Golgi compartment of the cell and leads to (i) a reduction in the production and processing of preprotein to mature BMP, (ii) tethering of pre-BMP to the cell surface, and (iii) an effective reduction in the secretion of mature BMP. http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12805376 http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12805376 http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#_4 http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o http://purl.org/dc/terms/created 2014-07-03T14:30:13.541+02:00 http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWZXaz0fx1chUWL-5rYp8kAsfWsYa2Jcmyt89oItpE0o http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234