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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#_5 http://www.w3.org/ns/prov#value Figure 4 Anti-apoptotic brakes at the mitochondrion. Black lines represent apoptotic pathways, red lines indicate inhibition. BCL2 (B-cell leukaemia lymphoma-2) and ?B-crystallin prevent mitochondrial release of the apoptogenic factors AIF (apoptosisinducing factor), cytochrome c (cyto c), HTRA2/OMI (high temperature requirement serine protease 2) and SMAC/DIABLO (second-mitochondrial-derived activator of caspases) into the cytosol by the binding and sequestration of BAX (B-cell lymphoma 2-associated protein X) and pro-apoptic BCL2 BAX-like molecules, BAK (BCL2 agonist killer 1) and BOK (BCL2-related ovarian killer protein) in the cytosol. APC (activated protein C) might prevent AIF release by increasing BCL2 expression. BAX translocation to the outer mitochondrial membrane is prevented by HSP70 (heat shock protein 70) and its co-chaperone HSP40(DNAJL1/DNAJL2). Meanwhile, membrane depolarization is prevented by the uncoupling properties of UCP2 (uncoupling protein 2) and the free radical scavenging properties of GIF (growth inhibitory factor). BH3, BCL2 homology domain 3; cIAP1, cellular apoptosis inhibitor 1; ENDOG, endonuclease G; HSP27, heat shock protein 27; IAP, inhibitor of apoptosis protein; XIAP, X-chromosome linked inhibitor of apoptosis protein. http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15322527 http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15322527 http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#_5 http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc http://purl.org/dc/terms/created 2014-07-03T14:30:27.155+02:00 http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWddSgYpinBAlISKZ0WZ2vNYiMsXNcvaHpuk5VK8b3wc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234