http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#Head http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#assertion http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#provenance http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#assertion http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_2 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9829 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_4 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6840 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_3 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_1 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:RAF1)) => kin(p(HGNC:MAP2K1)) http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_6 http://www.w3.org/ns/prov#value 124 However, Ras-mediated recruitment of C-Raf to the cell membrane and Src activation are not the only steps involved in the activation of C-Raf. A-Raf, which is structurally similar to C-Raf, is activated in a similar manner; however, the pertinent structural and activational aspects of B-Raf differ from those of A-Raf and C-Raf. Although the structural domains and phosphorylation sites of Raf proteins differ, the greater degree of phosphorylated amino acids in B-Raf confers a 15- to 20- fold higher level of kinase activity in the basal state than either A-Raf or C-Raf, and B-Raf is therefore a much more robust activator of ERK phosphorylation.85,144,145 The differential splicing of B-raf may also account for the distinct kinase activity of the protein. In addition, the structures of several B-Raf mutants mimic the conformational changes unique to phosphorylated wild-type B-Raf, which may explain the ability of B-Raf mutants to activate ERK in the absence of stimulation. Other interactions. In addition to phosphorylation events, the activation status of C-Raf is regulated by protein-protein and protein-lipid interactions. As shown in Figure 2, C-Raf interacts with a diverse array of scaffolding proteins (kinase suppressor of Ras and MEK partner-1), adaptor proteins (Bcl-2-associated athanogene-1), chaperone proteins (Hsp90 and Hsp70), substrates (retinoblastoma protein [Rb]), lipids (phosphatidic acid, cholesterol-rich caveolae, and cytosolic lipid rafts), and cellular constituents, many of which, in turn, modulate its kinase activity.95 Activation of Downstream Effectors by Raf Activated Raf principally propagates signaling by phosphorylating the two dual-specificity MAPKKs, MEK1 and MEK2 (also referred to as MKK1 and MKK2; Figs 1 and 2). 75 The Raf isoforms are the best characterized MEK1 and MEK2 activators, and all Raf isoforms activate MEK1, whereas only B-Raf and C-Raf activate MEK2. http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#_6 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://purl.org/dc/terms/created 2014-07-03T14:30:38.190+02:00 http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWek8Se7bb3zbnzDsnwIy8wWIz7BzjHfNAX_FzRE99N0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234