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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#_5 http://www.w3.org/ns/prov#value MITF in the commitment, proliferation, and survival of melanocytes before and/or during neural crest cell migration beta-catenin, a multifunctional protein which can either bind to E-cadherins as an integral part of the actin cytoskeleton which anchors cell cell adhesion, or can act as a transcriptional coactivator by interacting with the T-cell transcription factor (TCF)/lymphoid enhancer binding factor (LEF) family of DNA binding proteins in the nucleus. In the absence of Wnt-signals, beta-catenin is targeted for degradation via phosphorylation by a complex consisting of glycogen synthase kinase (GSK)3beta, axin, and adenomatous polyposis coli protein (APC). Wnt signals lead to inactivation of GSK3beta, and thus stabilize beta-catenin levels in the cell which increase transcription of downstream target genes. In human melanoma, stabilizing mutations of beta-catenin have been found in a significant fraction of established cell lines. Importantly, in primary human melanoma specimens, almost one third display aberrant nuclear accumulation of beta-catenin, although generally without evidence of direct mutations within the beta-catenin gene itself In mammalian cells, Wnt-3a, was also shown to induce MITF expression http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12235125 http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12235125 http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#_5 http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8 http://purl.org/dc/terms/created 2014-07-03T14:30:05.958+02:00 http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWgfSXbnlk0_-Y4B0Gm44rKz6NRRtY6f4nl4Ge4Ds_K8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234