. . . . . . . . . . . . . . . . . "cat(p(HGNC:TLR6)) -> kin(complex(NCH:\"p85/p110 PI3Kinase Complex\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . " PI3K. PI3Ks are activated during TLR/IL-1R signalling, as a result of the direct interaction of the PI3K p85 regulatory subunit with the receptor82. This interaction involves the SRC homology 2 (SH2) domain of the p85 subunit and a domain in the receptor containing the motif Tyr-Xaa-Xaa-Met. The subsequent association of the p110 catalytic subunit of PI3Ks results in complete activation, leading to the phosphorylation and activation of its downstream target, AKT. Interestingly, the PI3K-binding motif Tyr-Xaa-Xaa-Met, where Xaa denotes any amino acid, is present only in a subset of TLRs: TLR1, TLR2 and TLR6, but not TLR3, TLR4 or TLR5 (Ref. 83). However, a putative PI3K-binding site (Tyr257-Lys258-Ala259-Met260) is present in the C-terminus of MyD88, and LPS stimulation has been shown to result in the tyrosine phosphorylation of MyD88 and the formation of a PI3K-MyD88 complex84." . . "Selventa" . . . . "2014-07-03T14:30:25.417+02:00"^^ . . .