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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#_5 http://www.w3.org/ns/prov#value PI3K. PI3Ks are activated during TLR/IL-1R signalling, as a result of the direct interaction of the PI3K p85 regulatory subunit with the receptor82. This interaction involves the SRC homology 2 (SH2) domain of the p85 subunit and a domain in the receptor containing the motif Tyr-Xaa-Xaa-Met. The subsequent association of the p110 catalytic subunit of PI3Ks results in complete activation, leading to the phosphorylation and activation of its downstream target, AKT. Interestingly, the PI3K-binding motif Tyr-Xaa-Xaa-Met, where Xaa denotes any amino acid, is present only in a subset of TLRs: TLR1, TLR2 and TLR6, but not TLR3, TLR4 or TLR5 (Ref. 83). However, a putative PI3K-binding site (Tyr257-Lys258-Ala259-Met260) is present in the C-terminus of MyD88, and LPS stimulation has been shown to result in the tyrosine phosphorylation of MyD88 and the formation of a PI3K-MyD88 complex84. http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15229469 http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15229469 http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#_5 http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU http://purl.org/dc/terms/created 2014-07-03T14:30:25.417+02:00 http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWlFpwKO0ndlTc3ohYkpZVDB9zSTFPxl8i1UoxhD0ZxU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234