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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#_2 http://www.w3.org/ns/prov#value We found, when introduced into an interleukin 3-dependent cell line, TPR-MET induces factor independence and constitutive tyrosine phosphorylation of several cellular proteins. One major tyrosine phosphorylated protein was identified as the TPR-MET oncoprotein itself. Inhibition of the Met kinase activity by the novel small molecule drug SU11274 [(3Z)-N-(3-chlorophenyl)-3-([3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide] led to time- and dose-dependent reduced cell growth. http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14500382 http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14500382 http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#_2 http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs http://purl.org/dc/terms/created 2014-07-03T14:30:16.886+02:00 http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWrpgKtBKeAcRRELSVSf0gugFdU5eRyrtXn0na1g3bZs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234