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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#_6 http://www.w3.org/ns/prov#value The LPS-resistant mice were resistant to the indomethacin-induced impairment of CYP2D9. The mice were also less sensitive to the effects on CYP3A11 and CYP1A2, but the activities for these isozymes in the indomethacin-treated mice were still lower than in untreated mice. Immunoblot analysis with anti-CYP3A2 and anti-CYP2D2 sera indicated that indomethacin-induced decreases in expression of the proteins recognized by the antibodies were attenuated in the LPS-resistant mice. CONCLUSIONS: We conclude that Toll-like receptor 4 is involved in the indomethacin-induced down-regulation of hepatic CYP enzymes, indicating the pivotal role of gut-derived endotoxin in the hepatic effects. http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12927920 http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12927920 http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#_6 http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw http://purl.org/dc/terms/created 2014-07-03T14:30:15.845+02:00 http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXTAa3xk_pjIOgTIeOUE9i7Tr5KMZe8T9MzarrQpb5Cw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234