http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#Head http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#assertion http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#provenance http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_3 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6769 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_2 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_1 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#assertion http://www.w3.org/2000/01/rdf-schema#label kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| tscript(p(HGNC:SMAD3)) http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_5 http://www.w3.org/ns/prov#value The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY29004 reverses the ability of IGF-I to inhibit TGF-beta-induced transcriptional responses and the activation of Smad3, suggesting that the suppression of TGF-beta signaling by IGF-I is mediated through activation of PI3K. Moreover, we show that enforced expression of dominant-negative PI3K (DN-p85alpha) or phosphatidylinositol 3-phosphate-phosphatase, PTEN, also reverse the suppressive effect of IGF-I on TGF-beta-induced 3TP-luciferase reporter activity, whereas constitutively active PI3K (p110alphaCAAX) completely blocks TGF-beta-induced 3TP-luciferase reporter activity. http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12876289 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12876289 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#_5 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://purl.org/dc/terms/created 2014-07-03T14:30:14.889+02:00 http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXc7dLQSOvzIugGs_BVO60D8ZlLtvxwHmerfB8UF4dHE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234