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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#_4 http://www.w3.org/ns/prov#value PMID 10620507 We found previously that protein kinase C-z (PKC-z) can phosphorylate and activate Raf-1 in a signalling complex. We report now that PKCz-Raf-1 interaction is mediated by 14-3-3 proteins in ?itro and in ?i?o. the results suggest that 14-3-3 binds both PKC-z (at phospho-Ser-186) and Raf-1 ina ternary complex. Complex formation was much stronger with a kinase-inactive PKC-z mutant than with wild-type PKC-z, supporting the idea that kinase activity leads to complex dissociation 14-3-3B and Q with its putative PKCz phosphorylation sites mutated enhanced co-precipitation between PKC-z and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-z weakens the complex in in vivo http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10433554 http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10433554 http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#_4 http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY http://purl.org/dc/terms/created 2014-07-03T14:29:47.823+02:00 http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXgiwLI53FFMXvQI3uvG3I0iL9y1ak7LiYail8abHHnY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234