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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#_4 http://www.w3.org/ns/prov#value Several experimental evidences point to the possibility that FGF2 induces neovascularization indirectly by activation of the VEGF/ VEGFR system. Indeed: (i) VEGFR-2 antagonists inhibit both VEGF and FGF2-induced angiogenesis in vitro and in vivo [98]; (ii) expression of dominant-negative FGFR1 or FGFR2 in glioma cells results in a decrease in tumor vascularization paralleled by VEGF down-regulation [99]; (iii) both endogenous and exogenous FGF2 modulate VEGF expression in endothelial cells [82]; (iv) in the mouse cornea, the quiescent endothelium of vessels of the limbus express both VEGF mRNA and protein only after FGF2 treatment. In the same model, systemic administration of anti-VEGF-A neutralizing antibodies dramatically reduces FGF2-induced vascularization [82]; (v) VEGFR-1-blocking antibodies or the expression of a dominant-negative VEGFR-1 result in a significant reduction of FGF2-induced cell extensions and capillary morphogenesis [56]; (vi) FGF2 upregulates the expression of both FGFRs and VEGFRs in endothelial cells [100]. http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15863032 http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15863032 http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#_4 http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac http://purl.org/dc/terms/created 2014-07-03T14:30:34.811+02:00 http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXs9KTpZ2ogIyOvfWAohipGt-eIUQyR91Gt8tdY0rLac http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234