sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "1.4" .
  sub:_2 prov:value "Two mechanisms have been identified to explain how insulin receptors promote insulin secretion in b cells. Insulin stimulates exocytosis of secretory vesicles (Aspinwall et al., 1999); exocytosis of insulin feeds back to promote transcription of the insulin gene, an effect mediated by insulin receptors, IRS2, and PI 3-kinase (Leibiger et al., 1998). This role for IRS2 in b cells helps to explain the observation that IRS2 knockout mice developed diabetes because of failure of insulin secretion to compensate for insulin resistance" ;
    prov:wasQuotedFrom pubmed:10199397 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10199397 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}